OrangerV1, France, Analysis, bibRecord, 000156

Modulation of P‐glycoprotein activity by acridones and coumarins from Citrus sinensis

Identifieur interne : 000156 ( France/Analysis ); précédent : 000155; suivant : 000157

Modulation of P‐glycoprotein activity by acridones and coumarins from Citrus sinensis

Auteurs : C. Bayet [France] ; C. Fazio [France] ; N. Darbour [France] ; O. Berger [France] ; I. Raad [France] ; A. Chaboud [France] ; C. Dumontet [France] ; D. Guilet [France]

Source :

Phytotherapy Research [ 0951-418X ] ; 2007-04.

RBID : ISTEX:02BFB58CDA896AF7A3F07C7F669DF5233B59B2EE

Descripteurs français

Pascal (Inist)
- Acridine dérivé, Acridone dérivé, Citrus sinensis, Coumarine dérivé, Glycoprotéine P, Inhibiteur, Lactone, Origine végétale, Pharmacognosie, Plante médicinale.
Wicri :
- topic : Plante médicinale.

English descriptors

KwdEn :
- Acridine derivatives, Acridines (isolation & purification), Acridines (pharmacology), Cell Line, Tumor, Citrus sinensis, Citrus sinensis (chemistry), Coumarine derivatives, Coumarins (isolation & purification), Coumarins (pharmacology), Humans, Inhibitor, Lactone, Medicinal plant, Molecular Structure, P Glycoprotein, P-Glycoprotein (antagonists & inhibitors), Pharmacognosy, Plant Roots (chemistry), Plant origin, P‐glycoprotein inhibitors, acridones, coumarins.
MESH :
- chemical , antagonists & inhibitors : P-Glycoprotein.
- chemical , isolation & purification : Acridines, Coumarins.
- chemical , pharmacology : Acridines, Coumarins.
- chemistry : Citrus sinensis, Plant Roots.
- Cell Line, Tumor, Humans, Molecular Structure.

Abstract

Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2‐methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2‐methoxycitpressine I and acrimarine E inhibited P‐glycoprotein‐mediated drug efflux in K562/R7 human leukemic cells over‐expressing P‐glycoprotein. Copyright © 2007 John Wiley & Sons, Ltd.

Url:

https://api.istex.fr/document/02BFB58CDA896AF7A3F07C7F669DF5233B59B2EE/fulltext/pdf

DOI: 10.1002/ptr.2081

Affiliations:

Links to Exploration step

ISTEX:02BFB58CDA896AF7A3F07C7F669DF5233B59B2EE

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acridine derivatives</term>
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<term>Cell Line, Tumor</term>
<term>Citrus sinensis</term>
<term>Citrus sinensis (chemistry)</term>
<term>Coumarine derivatives</term>
<term>Coumarins (isolation & purification)</term>
<term>Coumarins (pharmacology)</term>
<term>Humans</term>
<term>Inhibitor</term>
<term>Lactone</term>
<term>Medicinal plant</term>
<term>Molecular Structure</term>
<term>P Glycoprotein</term>
<term>P-Glycoprotein (antagonists & inhibitors)</term>
<term>Pharmacognosy</term>
<term>Plant Roots (chemistry)</term>
<term>Plant origin</term>
<term>P‐glycoprotein inhibitors</term>
<term>acridones</term>
<term>coumarins</term>
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<front><div type="abstract" xml:lang="en">Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2‐methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2‐methoxycitpressine I and acrimarine E inhibited P‐glycoprotein‐mediated drug efflux in K562/R7 human leukemic cells over‐expressing P‐glycoprotein. Copyright © 2007 John Wiley & Sons, Ltd.</div>
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Modulation of P‐glycoprotein activity by acridones and coumarins from Citrus sinensis

Modulation of P‐glycoprotein activity by acridones and coumarins from Citrus sinensis

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Descripteurs français

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Abstract

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